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A likelihood-based approach for computing the operating characteristics of the 3+3 phase I clinical trial design with extensions to other A+B designs
BACKGROUND: In phase I clinical trials, the ‘3+3’ algorithmic design has been unparalleled in its popularity. The statistical properties of the ‘3+3’ design have been studied in the literature either in comparison with other methods or by deriving exact formulae of statistical quantities. However, t...
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| Publicado no: | Clin Trials |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4344878/ https://ncbi.nlm.nih.gov/pubmed/25349178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774514555585 |
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