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Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α–Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts
Synovial fibroblast proliferation is a hallmark of the invasive pannus in the rheumatoid joint. Activated protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in various diseases via endothelial protein C receptor (EPCR) and proteinase-activated recepto...
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| Udgivet i: | Mol Med |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
ScholarOne
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4344457/ https://ncbi.nlm.nih.gov/pubmed/24096826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2013.00034 |
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