Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: Results of 4 Phase III Trials

OBJECTIVE: Lp(a) is an independent, causal, genetic risk factor for cardiovascular disease and aortic stenosis. Current pharmacologic lipid-lowering therapies do not optimally lower Lp(a), particularly in patients with familial hypercholesterolemia (FH). APPROACH AND RESULTS: In four Phase III trial...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Santos, Raul D., Raal, MD Frederick J., Catapano, Alberico L., Witztum, Joseph L, Steinhagen-Thiessen, Elisabeth, Tsimikas, Sotirios
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344404/
https://ncbi.nlm.nih.gov/pubmed/25614280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.304549
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