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Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci

In humans, leukocyte telomere length (LTL) is positively correlated with lifespan, and shorter LTL is associated with increased risk of age-related disease. In this study we tested for association between telomere length and methylated cytosine levels. Measurements of mean telomere length and DNA me...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Buxton, Jessica L., Suderman, Matthew, Pappas, Jane J., Borghol, Nada, McArdle, Wendy, Blakemore, Alexandra I. F., Hertzman, Clyde, Power, Christine, Szyf, Moshe, Pembrey, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344300/
https://ncbi.nlm.nih.gov/pubmed/24828261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04954
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