A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland

Activation of an apical Ca(2+)-activated Cl(−) channel (CaCC) triggers the secretion of saliva. It was previously demonstrated that CaCC-mediated Cl(−) current and Cl(−) efflux are absent in the acinar cells of systemic Tmem16A (Tmem16A Cl(−) channel) null mice, but salivation was not assessed in fu...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Catalán, Marcelo A., Kondo, Yusuke, Peña-Munzenmayer, Gaspar, Jaramillo, Yasna, Liu, Frances, Choi, Sooji, Crandall, Edward, Borok, Zea, Flodby, Per, Shull, Gary E., Melvin, James E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343136/
https://ncbi.nlm.nih.gov/pubmed/25646474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415739112
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