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Crossovers are associated with mutation and biased gene conversion at recombination hotspots

Meiosis is a potentially important source of germline mutations, as sites of meiotic recombination experience recurrent double-strand breaks (DSBs). However, evidence for a local mutagenic effect of recombination from population sequence data has been equivocal, likely because mutation is only one o...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Arbeithuber, Barbara, Betancourt, Andrea J., Ebner, Thomas, Tiemann-Boege, Irene
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343121/
https://ncbi.nlm.nih.gov/pubmed/25646453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416622112
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