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An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

The nucleotide cyclic di-3′,5′- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP–producing bacteria, altered nucleotide levels result in several physiological defects and attenuated virulence. Thus, a de...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Huynh, TuAnh Ngoc, Luo, Shukun, Pensinger, Daniel, Sauer, John-Demian, Tong, Liang, Woodward, Joshua J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343097/
https://ncbi.nlm.nih.gov/pubmed/25583510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416485112
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