Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo

[Image: see text] Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work, we synthesize and characterize polymeric gene delivery nanoparticles and evaluate their effica...

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Pubblicato in:ACS Nano
Autori principali: Mangraviti, Antonella, Tzeng, Stephany Yi, Kozielski, Kristen Lynn, Wang, Yuan, Jin, Yike, Gullotti, David, Pedone, Mariangela, Buaron, Nitsa, Liu, Ann, Wilson, David R., Hansen, Sarah K., Rodriguez, Fausto J., Gao, Guo-Dong, DiMeco, Francesco, Brem, Henry, Olivi, Alessandro, Tyler, Betty, Green, Jordan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342728/
https://ncbi.nlm.nih.gov/pubmed/25643235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn504905q
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