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IQGAP1 controls tight junction formation through differential regulation of claudin recruitment

IQGAP1 is a scaffolding protein previously implicated in adherens junction formation. However, its role in the establishment or maintenance of tight junctions (TJs) has not been explored. We hypothesized that IQGAP1 could regulate TJ formation by modulating the expression and/or localization of junc...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Tanos, Barbara E., Perez Bay, Andres E., Salvarezza, Susana, Vivanco, Igor, Mellinghoff, Ingo, Osman, Mahasin, Sacks, David B., Rodriguez-Boulan, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342576/
https://ncbi.nlm.nih.gov/pubmed/25588839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.118703
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