Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes

Insulin receptor substrates (IRSs) have been shown to be major mediators of insulin signaling. Recently, we found that IRSs form high-molecular weight complexes, and here, we identify by yeast two-hybrid screening a novel IRS-1-associated protein: a 42-kDa cGMP-dependent protein kinase-anchoring pro...

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Vydáno v:J Biol Chem
Hlavní autoři: Ando, Yasutoshi, Shinozawa, Yusuke, Iijima, Yumi, Yu, Bu-Chin, Sone, Meri, Ooi, Yuko, Watanaka, Yusuke, Chida, Kazuhiro, Hakuno, Fumihiko, Takahashi, Shin-Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342495/
https://ncbi.nlm.nih.gov/pubmed/25586176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624759
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