Adiponectin Reduces Hepatic Stellate Cell Migration by Promoting Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Secretion

Hepatic stellate cells (HSC) are central players in liver fibrosis that when activated, proliferate, migrate to sites of liver injury, and secrete extracellular matrix. Obesity, a known risk factor for liver fibrosis is associated with reduced levels of adiponectin, a protein that inhibits liver fib...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ramezani-Moghadam, Mehdi, Wang, Jianhua, Ho, Vikki, Iseli, Tristan J., Alzahrani, Badr, Xu, Aimin, Van der Poorten, David, Qiao, Liang, George, Jacob, Hebbard, Lionel
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342468/
https://ncbi.nlm.nih.gov/pubmed/25575598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.598011
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