Ex vivo fucosylation of third-party human regulatory T cells enhances anti–graft-versus-host disease potency in vivo

Adoptive therapy with regulatory T cells (Tregs) to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation. We hypothesized that adding fucose to human Tregs, forming the Sialyl Lewis X moiety on P-selectin glycoprotein ligand-1, would i...

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發表在:Blood
Main Authors: Parmar, Simrit, Liu, Xiaoying, Najjar, Amer, Shah, Nina, Yang, Hong, Yvon, Eric, Rezvani, Katy, McNiece, Ian, Zweidler-McKay, Patrick, Miller, Leonard, Wolpe, Steve, Blazar, Bruce R., Shpall, Elizabeth J.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2015
主題:
Transplantation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342362/
https://ncbi.nlm.nih.gov/pubmed/25428215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-603449
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