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Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-called astrocyte-neuron lactate shuttle (ANLS) ar...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Jolivet, Renaud, Coggan, Jay S., Allaman, Igor, Magistretti, Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342167/
https://ncbi.nlm.nih.gov/pubmed/25719367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004036
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