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Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-called astrocyte-neuron lactate shuttle (ANLS) ar...

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Publicat a:PLoS Comput Biol
Autors principals: Jolivet, Renaud, Coggan, Jay S., Allaman, Igor, Magistretti, Pierre J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342167/
https://ncbi.nlm.nih.gov/pubmed/25719367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004036
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