Substitutions at Methionine 220 in the 14α-Sterol Demethylase (Cyp51A) of Aspergillus fumigatus Are Responsible for Resistance In Vitro to Azole Antifungal Drugs

Five clinical isolates of Aspergillus fumigatus that exhibited similar patterns of reduced susceptibility to itraconazole and other triazole drugs were analyzed. Sequence analysis of genes (cyp51A and cyp51B) encoding the 14α-sterol demethylases revealed that all five strains harbored mutations in c...

Description complète

Détails bibliographiques

Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Mellado, E., Garcia-Effron, G., Alcazar-Fuoli, L., Cuenca-Estrella, M., Rodriguez-Tudela, J. L.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2004
Sujets:	Mechanisms of Resistance
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434164/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2747-2750.2004
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!