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β-Catenin Links von Hippel-Lindau to Aurora Kinase A and Loss of Primary Cilia in Renal Cell Carcinoma

von Hippel-Lindau (VHL) gene mutations are associated with clear cell renal cell carcinoma (ccRCC). A hallmark of ccRCC is loss of the primary cilium. Loss of this key organelle in ccRCC is caused by loss of VHL and associated with increased Aurora kinase A (AURKA) and histone deacetylase 6 (HDAC6)...

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Библиографические подробности
Опубликовано в: :J Am Soc Nephrol
Главные авторы: Dere, Ruhee, Perkins, Ashley Lyn, Bawa-Khalfe, Tasneem, Jonasch, Darius, Walker, Cheryl Lyn
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Nephrology 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341469/
https://ncbi.nlm.nih.gov/pubmed/25313256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013090984
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