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Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli

5-Aminolevulinic acid (ALA), the committed intermediate of the heme biosynthesis pathway, shows significant promise for cancer treatment. Here, we identified that in addition to hemA and hemL, hemB, hemD, hemF, hemG and hemH are also the major regulatory targets of the heme biosynthesis pathway. Int...

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Pubblicato in:Sci Rep
Autori principali: Zhang, Junli, Kang, Zhen, Chen, Jian, Du, Guocheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341193/
https://ncbi.nlm.nih.gov/pubmed/25716896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08584
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