Phase I study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients

PURPOSE: To define the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) and pharmacokinetics (PK) of PEP02, a novel liposome-encapsulated irinotecan, in patients with advanced refractory solid tumors. METHODS: Patients were enrolled in cohorts of one to three to receive escalating dose of...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Chang, T. C., Shiah, H. S., Yang, C. H., Yeh, K. H., Cheng, A. L., Shen, B. N., Wang, Y. W., Yeh, C. G., Chiang, N. J., Chang, J. Y., Chen, L. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341010/
https://ncbi.nlm.nih.gov/pubmed/25577133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2671-x
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