Immunization with Brucella VirB Proteins Reduces Organ Colonization in Mice through a Th1-Type Immune Response and Elicits a Similar Immune Response in Dogs

VirB proteins from Brucella spp. constitute the type IV secretion system, a key virulence factor mediating the intracellular survival of these bacteria. Here, we assessed whether a Th1-type immune response against VirB proteins may protect mice from Brucella infection and whether this response can b...

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Bibliographic Details
Published in:Clin Vaccine Immunol
Main Authors: Pollak, Cora N., Wanke, María Magdalena, Estein, Silvia M., Delpino, M. Victoria, Monachesi, Norma E., Comercio, Elida A., Fossati, Carlos A., Baldi, Pablo C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340900/
https://ncbi.nlm.nih.gov/pubmed/25540276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00653-14
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