Phospholipid-binding Sites of Phosphatase and Tensin Homolog (PTEN): EXPLORING THE MECHANISM OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ACTIVATION

The lipid phosphatase activity of the tumor suppressor phosphatase and tensin homolog (PTEN) is enhanced by the presence of its biological product, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). This enhancement is suggested to occur via the product binding to the N-terminal region of the prot...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wei, Yang, Stec, Boguslaw, Redfield, Alfred G., Weerapana, Eranthie, Roberts, Mary F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340405/
https://ncbi.nlm.nih.gov/pubmed/25429968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.588590
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