BRCA1-associated Protein 1 (BAP1) Deubiquitinase Antagonizes the Ubiquitin-mediated Activation of FoxK2 Target Genes

BRCA1-associated protein 1 (BAP1), which is frequently mutated in cancer, functions as a deubiquitinase (DUB) for histone H2A. Although BAP1 interacts with a transcriptional regulator, HCF-1, and transcription factors FoxK1 and FoxK2, how BAP1 controls gene expression remains unclear. This study inv...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Okino, Yuki, Machida, Yuka, Frankland-Searby, Sarah, Machida, Yuichi J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340404/
https://ncbi.nlm.nih.gov/pubmed/25451922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609834
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