The DEAH-box Helicase Dhr1 Dissociates U3 from the Pre-rRNA to Promote Formation of the Central Pseudoknot

In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a univ...

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Pubblicato in:PLoS Biol
Autori principali: Sardana, Richa, Liu, Xin, Granneman, Sander, Zhu, Jieyi, Gill, Michael, Papoulas, Ophelia, Marcotte, Edward M., Tollervey, David, Correll, Carl C., Johnson, Arlen W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340053/
https://ncbi.nlm.nih.gov/pubmed/25710520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002083
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