Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we show that PINK1 can phosphorylate every Ub in Ub chains. Moreover, Ser65 phosphorylation alters Ub structure, generating two conformations in so...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Wauer, Tobias, Swatek, Kirby N, Wagstaff, Jane L, Gladkova, Christina, Pruneda, Jonathan N, Michel, Martin A, Gersch, Malte, Johnson, Christopher M, Freund, Stefan MV, Komander, David
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339119/
https://ncbi.nlm.nih.gov/pubmed/25527291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489847
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