Structural Flexibility of a Conserved Antigenic Region in Hepatitis C Virus Glycoprotein E2 Recognized by Broadly Neutralizing Antibodies

Neutralizing antibodies (NAbs) targeting glycoprotein E2 are important for the control of hepatitis C virus (HCV) infection. One conserved antigenic site (amino acids 412 to 423) is disordered in the reported E2 structure, but a synthetic peptide mimicking this site forms a β-hairpin in complex with...

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Udgivet i:J Virol
Main Authors: Meola, Annalisa, Tarr, Alexander W., England, Patrick, Meredith, Luke W., McClure, C. Patrick, Foung, Steven K. H., McKeating, Jane A., Ball, Jonathan K., Rey, Felix A., Krey, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338873/
https://ncbi.nlm.nih.gov/pubmed/25473061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02190-14
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