Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

BACKGROUND: Brain lipoprotein metabolism is dependent on lipoprotein particles that resemble plasma high‐density lipoproteins but that contain apolipoprotein (apo) E rather than apoA‐I as their primary protein component. Astrocytes and microglia secrete apoE but not apoA‐I; however, apoA‐I is detect...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Stukas, Sophie, Robert, Jerome, Lee, Michael, Kulic, Iva, Carr, Michael, Tourigny, Katherine, Fan, Jianjia, Namjoshi, Dhananjay, Lemke, Kalistyne, DeValle, Nicole, Chan, Jeniffer, Wilson, Tammy, Wilkinson, Anna, Chapanian, Rafi, Kizhakkedathu, Jayachandran N., Cirrito, John R., Oda, Michael N., Wellington, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338702/
https://ncbi.nlm.nih.gov/pubmed/25392541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001156
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