Active Site Loop Conformation Regulates Promiscuous Activity in a Lactonase from Geobacillus kaustophilus HTA426

Enzyme promiscuity is a prerequisite for fast divergent evolution of biocatalysts. A phosphotriesterase-like lactonase (PLL) from Geobacillus kaustophilus HTA426 (GkaP) exhibits main lactonase and promiscuous phosphotriesterase activities. To understand its catalytic and evolutionary mechanisms, we...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Yu, An, Jiao, Yang, Guang-Yu, Bai, Aixi, Zheng, Baisong, Lou, Zhiyong, Wu, Geng, Ye, Wei, Chen, Hai-Feng, Feng, Yan, Manco, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338136/
https://ncbi.nlm.nih.gov/pubmed/25706379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115130
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