The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III

INTRODUCTION: The blood coagulation system is a tightly regulated balance of procoagulant and anticoagulant factors, disruption of which can cause clinical complications. Diabetics are known to have a hypercoagulable phenotype, along with increased circulating levels of methylglyoxal (MGO) and decre...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Thromb Res
Main Authors: Jacobson, Richard, Mignemi, Nicholas, Rose, Kristie, O’Rear, Lynda, Sarilla, Suryakala, Hamm, Heidi E., Barnett, Joey V., Verhamme, Ingrid M., Schoenecker, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337957/
https://ncbi.nlm.nih.gov/pubmed/25307422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2014.09.038
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares