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The Pancreatic β-Cell Recognition of Insulin Secretagogues: Does Cyclic AMP Mediate the Effect of Glucose?

Insulin release and the content of cAMP were studied in microdissected pancreatic islets of noninbred ob/ob (obese) mice. In the absence of 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, 20 mM glucose had no effect on cAMP save a very small initial rise detectable by a freeze-stop perif...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Hellman, B., Idahl, L.-Å., Lernmark, Å., Täljedal, I.-B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1974
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433781/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4372618/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.9.3405
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