Novel Nrf2 activators from microbial transformation products inhibit blood–retinal barrier permeability in rabbits

BACKGROUND AND PURPOSE: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes. Activation of the Nrf2 pathway...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Nakagami, Yasuhiro, Masuda, Kayoko, Hatano, Emiko, Inoue, Tatsuya, Matsuyama, Takuya, Iizuka, Mayumi, Ono, Yasunori, Ohnuki, Takashi, Murakami, Yoko, Iwasaki, Masaru, Yoshida, Kazuhiro, Kasuya, Yuji, Komoriya, Satoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337698/
https://ncbi.nlm.nih.gov/pubmed/25363737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12999
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