Design, Synthesis and Application of Fluorine-Labeled Taxoids as (19)F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems

Novel tumor-targeting drug conjugates, BLT-F(2) (1) and BLT-S-F(6) (2), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker, and biotin as the tumor-targeting module, were designed and synthesized as (19)F NMR probes. Fluorine atoms and CF(3) groups were strateg...

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Pubblicato in:J Fluor Chem
Autori principali: Seitz, Joshua D., Vineberg, Jacob G., Wei, Longfei, Khan, Jonathan F., Lichtenthal, Brendan, Lin, Chi-Feng, Ojima, Iwao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337250/
https://ncbi.nlm.nih.gov/pubmed/25722499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2014.08.006
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