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Design, Synthesis and Application of Fluorine-Labeled Taxoids as (19)F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems
Novel tumor-targeting drug conjugates, BLT-F(2) (1) and BLT-S-F(6) (2), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker, and biotin as the tumor-targeting module, were designed and synthesized as (19)F NMR probes. Fluorine atoms and CF(3) groups were strateg...
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| Publicado no: | J Fluor Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337250/ https://ncbi.nlm.nih.gov/pubmed/25722499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2014.08.006 |
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