Design, Synthesis and Application of Fluorine-Labeled Taxoids as (19)F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems

Novel tumor-targeting drug conjugates, BLT-F(2) (1) and BLT-S-F(6) (2), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker, and biotin as the tumor-targeting module, were designed and synthesized as (19)F NMR probes. Fluorine atoms and CF(3) groups were strateg...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Fluor Chem
Главные авторы: Seitz, Joshua D., Vineberg, Jacob G., Wei, Longfei, Khan, Jonathan F., Lichtenthal, Brendan, Lin, Chi-Feng, Ojima, Iwao
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337250/
https://ncbi.nlm.nih.gov/pubmed/25722499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2014.08.006
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы