The Initial Uridine of Primary piRNAs Does not Create the Tenth Adenine That is the Hallmark of Secondary piRNAs

PIWI-interacting RNAs (piRNAs) silence transposons in animal germ cells. PIWI proteins bind and amplify piRNAs via the “Ping-Pong” pathway. Because PIWI proteins cleave RNAs between target nucleotides t10 and t11—the nucleotides paired to piRNA guide positions g10 and g11—the first ten nucleotides o...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Wang, Wei, Yoshikawa, Mayu, Han, Bo W., Izumi, Natsuko, Tomari, Yukihide, Weng, Zhiping, Zamore, Phillip D.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337030/
https://ncbi.nlm.nih.gov/pubmed/25453759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.016
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