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Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

The activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), the rate-limiting enzyme of hepatic cholesterol biosynthesis, is suppressed in human fibroblasts cultured in the presence of serum. This enzyme activity increases by more than 10-fold after the removal of serum from the m...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Brown, Michael S., Dana, Suzanna E., Goldstein, Joseph L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1973
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433688/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4352976/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.7.2162
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