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Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso peptide from an understudied halophilic actinomycete

Natural products are the most historically significant source of compounds for drug development. However, unacceptably high rates of compound rediscovery associated with large-scale screening of common microbial producers have resulted in the abandonment of many natural product drug discovery effort...

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Dettagli Bibliografici
Pubblicato in:Chem Biol
Autori principali: Metelev, Mikhail, Tietz, Jonathan I., Melby, Joel O., Blair, Patricia M., Zhu, Lingyang, Livnat, Itamar, Severinov, Konstantin, Mitchell, Douglas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336579/
https://ncbi.nlm.nih.gov/pubmed/25601074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.11.017
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