Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells

BACKGROUND: Non-alcoholic steatohepatitis (NASH) is associated with hepatic fibrogenesis. Despite well-known cholesterol-lowering action of statins, their mechanisms against NASH-mediated fibrogenesis remain unclear. This study aimed at investigating the in vitro and in vivo anti-fibrotic properties...

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Bibliographic Details
Published in:BMC Gastroenterol
Main Authors: Chong, Lee-Won, Hsu, Yi-Chao, Lee, Ting-Fang, Lin, Yun, Chiu, Yung-Tsung, Yang, Kuo-Ching, Wu, Jaw-Ching, Huang, Yi-Tsau
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336504/
https://ncbi.nlm.nih.gov/pubmed/25886887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12876-015-0248-8
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