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Carbon Dioxide Hydration Activity of Carbonic Anhydrase: Paradoxical Consequences of the Unusually Rapid Catalysis

The kinetic parameters for carbon dioxide hydration catalysis by carbonic anhydrase (EC 4.2.1.1) present an apparent paradox. The assumption of H(2)CO(3) as the hydration product requires the rate of recombination of H(2)CO(3) with enzyme to be faster than the diffusion limit. The alternative assump...

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Pubblicato in:Proc Natl Acad Sci U S A
Autore principale: Khalifah, Raja G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1973
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433648/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4198662/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.7.1986
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