Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study

BACKGROUND: Neutrophil elastase plays an important role in the development and progression of acute respiratory distress syndrome (ARDS). Although the selective elastase inhibitor, sivelestat, is widely used in Japan for treating ARDS patients, its effectiveness remains controversial. The aim of the...

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Detalhes bibliográficos
Publicado no:J Intensive Care
Main Authors: Tagami, Takashi, Tosa, Ryoichi, Omura, Mariko, Fukushima, Hidetada, Kaneko, Tadashi, Endo, Tomoyuki, Rinka, Hiroshi, Murai, Akira, Yamaguchi, Junko, Yoshikawa, Kazuhide, Saito, Nobuyuki, Uzu, Hideaki, Kase, Yoichi, Takatori, Makoto, Izumino, Hiroo, Nakamura, Toshiaki, Seo, Ryutarou, Kitazawa, Yasuhide, Sugita, Manabu, Takahashi, Hiroyuki, Kuroki, Yuichi, Irahara, Takayuki, Kanemura, Takashi, Yokota, Hiroyuki, Kushimoto, Shigeki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336272/
https://ncbi.nlm.nih.gov/pubmed/25705423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40560-014-0067-y
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