Thrombomodulin protects against lung damage created by high level of oxygen with large tidal volume mechanical ventilation in rats

BACKGROUND: Ventilator-induced lung injury (VILI) is associated with inflammatory responses in the lung. Thrombomodulin (TM), a component of the coagulation system, has anticoagulant and anti-inflammatory effects. We hypothesized that the administration of recombinant human soluble TM (rhsTM) would...

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Bibliografische gegevens
Gepubliceerd in:J Intensive Care
Hoofdauteurs: Iwashita, Yoshiaki, Zhang, Erquan, Maruyama, Junko, Yokochi, Ayumu, Yamada, Yasuharu, Sawada, Hirofumi, Mitani, Yoshihide, Imai, Hiroshi, Suzuki, Koji, Maruyama, Kazuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336269/
https://ncbi.nlm.nih.gov/pubmed/25705415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40560-014-0057-0
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