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Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies

PURPOSE: Immunomodulatory mAbs can treat cancer, but cures are rare except for small tumors. Our objective was to explore whether the therapeutic window increases by combining mAbs with different modes of action and injecting them into tumors. EXPERIMENTAL DESIGN: Combinations of mAbs to CD137/PD-1/...

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Bibliografische gegevens
Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Dai, Min, Yip, Yuen Yee, Hellstrom, Ingegerd, Hellstrom, Karl Erik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336234/
https://ncbi.nlm.nih.gov/pubmed/25142145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1339
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