Enantiospecific Reassessment of the Pharmacokinetics and Pharmacodynamics of Oral Eflornithine against Late-Stage Trypanosoma brucei gambiense Sleeping Sickness

This study aimed to characterize the stereoselective pharmacokinetics of oral eflornithine in 25 patients with late-stage Trypanosoma brucei gambiense sleeping sickness. A secondary aim was to determine the concentrations of l- and d-eflornithine required in plasma or cerebrospinal fluid (CSF) for a...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Jansson-Löfmark, R., Na-Bangchang, K., Björkman, S., Doua, F., Ashton, M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335853/
https://ncbi.nlm.nih.gov/pubmed/25512417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04101-14
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