Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

Chronic manganese (Mn) exposure produces a neurological syndrome with psychiatric, cognitive, and parkinsonian features. Gene expression profiling in the frontal cortex of Cyno-mologous macaques receiving 3.3–5.0 mg Mn/kg weekly for 10 months showed that 61 genes were increased and four genes were d...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Guilarte, Tomás R., Burton, Neal C., Verina, Tatyana, Prabhu, Vinaykumar V., Becker, Kevin G., Syversen, Tore, Schneider, Jay S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335763/
https://ncbi.nlm.nih.gov/pubmed/18284614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05295.x
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