Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

BACKGROUND: In northern Papua New Guinea (PNG), most Plasmodium falciparum isolates proved resistant to chloroquine (CQ) in vitro between 2005 and 2007, and there was near-fixation of pfcrt K76T, pfdhfr C59R/S108N and pfmdr1 N86Y. To determine whether the subsequent introduction of artemisinin combi...

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Bibliographic Details
Published in:	Malar J
Main Authors:	Koleala, Tamarah, Karl, Stephan, Laman, Moses, Moore, Brioni R, Benjamin, John, Barnadas, Celine, Robinson, Leanne J, Kattenberg, Johanna H, Javati, Sarah, Wong, Rina PM, Rosanas-Urgell, Anna, Betuela, Inoni, Siba, Peter M, Mueller, Ivo, Davis, Timothy ME
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2015
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4335551/ https://ncbi.nlm.nih.gov/pubmed/25626445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0560-3
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Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

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