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Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus

Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop. In Drosophila, nuclear entry of the clock proteins, PERIOD (PER) and TIMELESS (TIM), is tightly con...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Jang, A. Reum, Moravcevic, Katarina, Saez, Lino, Young, Michael W., Sehgal, Amita
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335507/
https://ncbi.nlm.nih.gov/pubmed/25674790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004974
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