Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial

IMPORTANCE: Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models. OBJECTIVE: To determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or b...

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Publicado no:JAMA
Main Authors: Shankaran, Seetha, Laptook, Abbot R., Pappas, Athina, McDonald, Scott. A., Das, Abhik, Tyson, Jon E., Poindexter, Brenda B., Schibler, Kurt, Bell, Edward F., Heyne, Roy J., Pedroza, Claudia, Bara, Rebecca, Van Meurs, Krisa P., Grisby, Cathy, Petrie Huitema, Carolyn M., Garg, Meena, Ehrenkranz, Richard A., Shepherd, Edward G., Chalak, Lina F., Hamrick, Shannon E. G., Khan, Amir M., Reynolds, Anne Marie, Laughon, Matthew M., Truog, William E., Dysart, Kevin C., Carlo, Waldemar A., Walsh, Michele C., Watterberg, Kristi L., Higgins, Rosemary D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335311/
https://ncbi.nlm.nih.gov/pubmed/25536254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2014.16058
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