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Leukotriene-C(4) Synthase, a Critical Enzyme in the Activation of Store-independent Orai1/Orai3 Channels, Is Required for Neointimal Hyperplasia

Leukotriene-C(4) synthase (LTC(4)S) generates LTC(4) from arachidonic acid metabolism. LTC(4) is a proinflammatory factor that acts on plasma membrane cysteinyl leukotriene receptors. Recently, however, we showed that LTC(4) was also a cytosolic second messenger that activated store-independent LTC(...

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Pubblicato in:J Biol Chem
Autori principali: Zhang, Wei, Zhang, Xuexin, González-Cobos, José C., Stolwijk, Judith A., Matrougui, Khalid, Trebak, Mohamed
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335238/
https://ncbi.nlm.nih.gov/pubmed/25540197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625822
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