Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn(2+)-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase

Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and zebrafish ADPRibase-Mn, the only biochemicall...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cabezas, Alicia, Ribeiro, João Meireles, Rodrigues, Joaquim Rui, López-Villamizar, Iralis, Fernández, Ascensión, Canales, José, Pinto, Rosa María, Costas, María Jesús, Cameselle, José Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334965/
https://ncbi.nlm.nih.gov/pubmed/25692488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118680
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