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Addressing population-specific multiple testing burdens in genetic association studies

The number of effectively independent tests performed in genome-wide association studies and the corresponding genome-wide significance level varies by population. Therefore, a common p-value threshold may be inappropriate. To assess this, we estimated the number of independent SNPs for all Phase 3...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Ann Hum Genet
Main Authors: SOBOTA, RAFAL S., SHRINER, DANIEL, KODAMAN, NURI, GOODLOE, ROBERT, ZHENG, WEI, GAO, YU-TANG, EDWARDS, TODD L., AMOS, CHRISTOPHER I., WILLIAMS, SCOTT M.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334751/
https://ncbi.nlm.nih.gov/pubmed/25644736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ahg.12095
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