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Mechanism of RecQ helicase mechanoenzymatic coupling reveals that the DNA interactions of the ADP-bound enzyme control translocation run terminations

The processing of various DNA structures by RecQ helicases is crucial for genome maintenance in both bacteria and eukaryotes. RecQ helicases perform active destabilization of DNA duplexes, based on tight coupling of their ATPase activity to moderately processive translocation along DNA strands. Here...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Sarlós, Kata, Gyimesi, Máté, Kele, Zoltán, Kovács, Mihály
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333385/
https://ncbi.nlm.nih.gov/pubmed/25539922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1333
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