Inhibited Wnt Signaling Causes Age-Dependent Abnormalities in the Bone Matrix Mineralization in the Apert Syndrome FGFR2(S252W/+) Mice

Apert syndrome (AS) is a type of autosomal dominant disease characterized by premature fusion of the cranial sutures, severe syndactyly, and other abnormalities in internal organs. Approximately 70% of AS cases are caused by a single mutation, S252W, in fibroblast growth factor receptor 2 (FGFR2). T...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Li, Chen, Peng, Chen, Lin, Weng, Tujun, Zhang, Shichang, Zhou, Xia, Zhang, Bo, Liu, Luchuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333342/
https://ncbi.nlm.nih.gov/pubmed/25693202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112716
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