Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

Avian influenza A (H5N1) viruses cause severe disease in humans(1,2), but the basis for their virulence remains unclear. In vitro and animal studies indicate that high and disseminated viral replication is important for disease pathogenesis(3,4,5). Laboratory experiments suggest that virus-induced c...

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Publicado no:Nat Med
Main Authors: de Jong, Menno D, Simmons, Cameron P, Thanh, Tran Tan, Hien, Vo Minh, Smith, Gavin J D, Chau, Tran Nguyen Bich, Hoang, Dang Minh, Van Vinh Chau, Nguyen, Khanh, Truong Huu, Dong, Vo Cong, Qui, Phan Tu, Van Cam, Bach, Ha, Do Quang, Guan, Yi, Peiris, J S Malik, Chinh, Nguyen Tran, Hien, Tran Tinh, Farrar, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333202/
https://ncbi.nlm.nih.gov/pubmed/16964257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1477
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