Flexible Stoichiometry and Asymmetry of the PIDDosome Core Complex by Heteronuclear NMR Spectroscopy and Mass Spectrometry

Homotypic death domain (DD)–DD interactions are important in the assembly of oligomeric signaling complexes such as the PIDDosome that acts as a platform for activation of caspase-2-dependent apoptotic signaling. The structure of the PIDDosome core complex exhibits an asymmetric three-layered arrang...

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Publicado en:J Mol Biol
Main Authors: Nematollahi, Lily A., Garza-Garcia, Acely, Bechara, Chérine, Esposito, Diego, Morgner, Nina, Robinson, Carol V., Driscoll, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332690/
https://ncbi.nlm.nih.gov/pubmed/25528640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.11.021
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