The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated α-Synuclein Dimerisation

α-synuclein (α-syn) is a major component of the intracellular inclusions called Lewy bodies, which are a key pathological feature in the brains of Parkinson’s disease patients. The neurotransmitter dopamine (DA) inhibits the fibrillisation of α-syn into amyloid, and promotes α-syn aggregation into S...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Leong, Su Ling, Hinds, Mark G., Connor, Andrea R., Smith, David P., Illes-Toth, Eva, Pham, Chi L. L., Barnham, Kevin J., Cappai, Roberto
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332483/
https://ncbi.nlm.nih.gov/pubmed/25679387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116497
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